By unlocking the secrets of a bizarre virus that survives in nearly boiling acid, scientists at the University of Virginia School of Medicine have found a blueprint for battling human disease using DNA clad in near-indestructible armor. "What's interesting and unusual is being able to see how proteins and DNA can be put together in a way that's absolutely stable under the harshest conditions imaginable," said Edward H. Egelman, PhD, of the UVA Department of Biochemistry and Molecular Genetics. "We've discovered what appears to be a basic mechanism of resistance -- to heat, to desiccation, to ultraviolet radiation. And knowing that, then, we can go in many different directions, including developing ways to package DNA for gene therapy."
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